RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Tnf
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
Masson's trichrome staining; LUMA; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
Alterations in DNA methylation corresponding with lung inflammation and as a biomarker for disease development after MWCNT exposure
Year
2016
Function
"MWCNT lead to DNA hypomethylation in the lung and blood, which coincided with disease development. Alterations in gene-specific methylation correspond with an inflammatory response to MWCNT exposure. In addition, global DNA methylation in the lung and blood coincides with MWCNT-induced disease development, suggesting its potential as a biomarker of both exposure and disease development."